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In addition, metformin suppresses VEGF expression through the mTORC1/HIF-1α pathway, further indicating its anti-angiogenic properties in uterine fibroids (Tadakawa et al., 2015)

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Although the absence of lamin B1 initially promotes neurogenesis, it ultimately depletes the stem cell pool and reduces the survival of newly formed neurons, leading to a significant decline in neurogenic capacity